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Probandenaufruf!

Schlafen im Dienste der Wissenschaft

Beeinflussen β-Blocker den Schlaf in der Höhe? Diese Frage stellte sich uns als sich im vergangenen Jahr zwei Patienten bei uns mit Schlafproblemen im Urlaub in Südtirol vorstellten. Unseren Messungen zufolge stellte sich bei den beiden Patienten bereits bei 1500m das Phänomen der periodischen Atmung ein. Normalerweise tritt dies bei Gesunden erst in deutlich höheren Regionen auf. Nach eingehenden Untersuchungen stellte sich heraus, dass der ß-Blocker die adäquate Anpassung der Herzfrequenz verhindert und die Entstehung von wiederkehrenden Atemaussetzern (periodischer Atmung) befördert.

Wir möchten diesen Umstand wissenschaftlich ergründen und suchen in diesem Zusammenhang Probanden die:

  • älter als 40 Jahre alt sind
  • einen ß-Blocker einnehmen (z.B. Bisoprolol od. Metoprolol)
  • keine Herzinsuffizienz haben

Ablauf der Tests:

1.      Voruntersuchung: Zur Voruntersuchung werden Sie von uns eingeladen. Diese dauert etwa 30 Minuten. Hier werden vor Allem Ihre anthropometrischen Daten Größe, Gewicht und BMI ermittelt. Außerdem wird eine Herzechokardiographie durchgeführt, um Ihre Herzfunktion zu analysieren. (Auswurffraktion) Der Herzultraschall ist ein nicht invasives Messverfahren, das keine Risiken birgt.

2.      Erste Testnacht: Sollten Sie zur Studienteilnahme geeignet sein, werden Sie von uns informiert und zum ersten Schlaftermin eingeladen. Gegen 21 Uhr werden Sie bei uns an ein Schlaflabor angeschlossen. Dieses Messinstrument erhebt eine Vielzahl von Daten wie Puls, EKG, EEG, Bauch und Brustbewegungen und Sauerstoff im Blut. Unser Augenmerk liegt dabei vor Allem auf Ihrer Atemtätigkeit. Diese Untersuchung ist ebenfalls nicht invasiv und läuft über Nacht weiter, während Sie schlafen. Am Morgen können Sie je nach Wunsch zwischen 6 und 8 Uhr unseren Höhenschlafraum verlassen und die Messung beenden.

3.      Zweite Testnacht: Die zweite Messung findet mindestens eine Woche später statt und läuft genauso wie die erste Nacht ab.

SchlaflaborSie werden die beiden Nächte in unserer Höhenkammer verbringen. In diese können wir den Sauersoffgehalt in der Luft derart verringern können, dass ähnliche Bedingungen wie auf 1500m herrschen. Sie schlafen also ohne Atemmaske und können sich nachts falls nötig frei in unserem Schlafraum und dem angrenzenden Bad bewegen.

Da diese Studie verblindet ist werden Sie nicht wissen in welcher Nacht Sie auf 450m und auf 1500m simulierter Höhe schlafen. Nach Ablauf der Studie können wir Ihnen gerne darüber Auskunft geben.

Sollten Sie noch weitere Fragen haben und Interesse an einer Teilnahme haben kontaktieren Sie und bitte!


Hypoxia physiology symposium memorzing Hermann Buhls 90th birthday at the medical education center of UH in Honolulu

On Dec. 16th, Ralph Sohet MD PhD, chairman of the Cardiovascular research center at the Medical School of the University of Hawaii in Honolulu, Prof. em. Bruce Soll MD from Queens Medical Center in Honolulu and our group with master course students and research members of UIBK have held a very fruitful brainstorming symposium open to the public.

Prof. Soll reported on sleep positioning in relation to intrathoracical fluid in patients with heart failure. Data from the publication in Sleep 2009 and new data from his coworker. Prof. Sohet reported on his work  of  doxycyclin take way triggered extended HIF function in mice hearts and how micro RNA of gene C19 can adverse this extended hypoxic effect. In the far future maybe one possible intervention on hypoxic human hearts.

Our group reported about cardio rehabilitation in geriatric patients in moderate hypoxia (Stephan Pramsohler), the study protocol of the Mauna Kea normobaric-hypobaric hypoxia comparison study (Linda Rausch and Matthias Fries), cardio events in scuba diving (Nicolai Szenlenzcy) , cardio events in alpine skiing (Lukas Höllriegl), Chronic Hypoxia in Chilean Mine Workers (Maike Huth), Ergospirometry with forced steps at 7000m altitude and at Everest base camp (Hanno Fröhlich), the life of Hermann Buhl and Hif and fat metabolism (Nikolaus Netzer).

Long and active discussions followed each presentation and left the feeling that every participant really profitted from this half day brainstorming symposium.

N. Netzer

 

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Last study leg not performed. Due to successful third leg no change in study outcome.

The last of the planned four study legs has not been performed. This is fortunately not harming the outcome of the main parameters of the study protocol: 1. Comparison of shape of flow volume curve in normobaric and hypobaric hypoxia. 2. Comparison of VO2max ml/kg 3. Comparison of SaO2 values and Lake Louise Score during hike (hypobaric) and simulated hike (normobaric), because all measurements already worked fine on the third leg (hypobaric hike on Mauna Kea).  The last leg was to prove if an overnight stay at a moderate altitude of 2000-2800m would change outcome on some of the parameters based on a new theory that already a few hours at moderate altitude deliver enough acclimatization.

After the third leg there was some argueing with administrative officials of the Mauna Kea UH administration due to a ranger intervention transporting three study volounteers down from summit to our second parked car at the visitor center, because they seemed mountain sick. Therefore Mauna Kea UH administration did not allow us to stay overnight near the visitor center at 2800m and the state park camp site at 2200m was closed. A plan B to stay at 2200m at a parking spot near the start of the road to the Mauna Loa weather observatory, first agreed on by all participants, failed because three study members did not volounteer on the actual day and performing the leg with just three volounteers wouldn’t have made sense. N.Netzer

 

Picture: Students at 3200m on Humuula trail on third study leg. Mauna Loa in the background

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A big „thank you“ to our supporters Vice Dean Inge Werner PhD Ibk, Ralph Sohet MD PhD at UH, Blue Wilderness Waikoloa, Blue Sub Rosenheim and George Kaimana

I would like to express my great thanks to those, who supported the study and the trip.

Within the faculty and division of sports science at Innsbruck I would like to especially thank vice dean Inge Werner and my mentor Martin Burtscher for making the excursion and master course possible. Of course a big thank has to been expressed to the chairman of the Division of  Cardiologic Research at UH in Honolulu, Ralph Sohet, for putting up a symposium, which also helped to make the excursion a master course with presentations for the students and adding extrem more educational value. A big „thank you“ also to his boss,  dean Jerris Hedges, who gave his ok and made all possible.

Thank has of course to be expressed to our sponsors, Blue Sub Rosenheim supported us with a value of 250€ and Blue Wilderness in Waikoloa with an equal reduction in rental fee.

Students were impressed by Blue Sub and it’s owner Marianne, with her authority on scuba gear, diving dicipline and cold water diving.

Dave and Denise and their team from Blue Wilderneess, located at Waikoloa’s Queens Market, are always helpful and try to fulfill even difficult customer needs. The often sublime arrogance, with which some Pro’s treat recreational divers in other dive shops, is a no go at Blue Wilderness. I was absolutely happy, when Blue Wilderness opened in Waikoloa, making it easy and relaxed to return dive tanks after dives at Kohala’s beautiful coasts. Their 25 tank card makes it easy at a great price for the avid diver to use great shore dive days with low swell or do a different activity on a day, when diving would be somewhat turning up and down your stomach (what is rare in December).

Finally George Kaimana, native and at least a quarter real Hawaian descent, showed us what real Hawaian hospitality means. George took the students and my folks stand up paddeling (if one becomes tired it should be renamed knee or sit paddeling) serveral times and showed us the Spinner Dolphins, Manta Rays and Whales near Kona harbour pier. It was great. We also have to thank George for gratious gifts, like coffee from his own coffee plantation and lunch invitations. George Kaimana grew up on a coffee plantation, but then took coffee farming to a academic level after visting college in Hawaii and courses at Cornel University’s Hawaian Educational program. He now manages coffee plantations not only in Hawaii but also in many other areas of the world. For this job he doesn’t have to travel much. Modern communication makes it possible to advise submanagers at other plantations to follow George’s advice via Skype or email accompanied by pictures and videos. If these activities aren‘ t filling his day, George works as life guard on Kona and Kohala beaches and he bodygards VIP’s. He can’t talk about his customers but gave us a hint that two German supermodels were among them. Well, I only know two and so I am guessing that Claudia and Heidi made it to Big Island meanwhile.

Pictures: Prof. Ralph Sohet, Marianne from Blue Sub, Blue Wilderness Store at Waikoloa, George Kaimana

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Our day off…

Maike and I were stand-up paddeling with some dolphins today (about 20). A really nice local guy, George, took the lead and showed them to us at Kona Beach. We were paddeling with them for about 4 hours. Now preparing for the night on the mountain site in a tent, before it goes up again to the top of Mauna Kea in the morning :) 10858585_10203548807786719_6871055902119731758_n


Trip to the north shore of big island

Today dr. Netzer and two students went to discover the northern part of our beautiful island.

First we stopped at a wonderful sandy beach an enjoyed the calm sea and the blue sky. With a stop in hawi we had a tipical hawaiian pulled pork sandwiche at a bbq wagon. A few miles later we were standing at the northest part of the Island and took the short walk down the trail. There we found a wonderful black lava sand beach between the cliffs. We were fascinated about the sudden change of the vegetation. Around our guest house is the dry vulcanic landscape and in the north we were sourounded by lots of trees and a rainforest like vegetation. We had a blast of the impressing environment so the rain which catched us did not change our mood at all.

We are glade to have such an opportunity to participate in such a research and enjoying big island hawaii.

Greetings nico and lukas

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